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Figure 4 | Cancer Cell International

Figure 4

From: Activity of histone deacetylase inhibitors and an Aurora kinase inhibitor in BCR-ABL-expressing leukemia cells: Combination of HDAC and Aurora inhibitors in BCR-ABL-expressing cells

Figure 4

Effects of vorinostat or pracinostat in combination with tozasertib in BCR-ABL-positive cells. (A) K562 cells were treated with vorinostat or pracinostat and/or tozasertib for 24 h. Total cell lysates were immunoblotted with anti-survivin, -Aurora A and B, and -cleaved PARP Abs. Actin or tubulin was used as the loading control. Band intensities were quantified using ImageJ software. (B) K562 cells were treated with HDAC inhibitors (vorinostat or pracinostat) and/or tozasertib for 72 h. The number of viable cells was calculated for each group. (C) Ba/F3 T315I cells were treated with HDAC inhibitors (vorinostat or pracinostat) and/or tozasertib for 72 h. The number of viable cells was calculated for each group. Results in A, B, and C are representative of at least 3 reproducible experiments.

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Cancer Cell International

ISSN: 1475-2867

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