Table 1 Characteristics of accelerated host aging in tumours and in the non-cancerous LFS host
From: Li Fraumeni syndrome, cancer and senescence: a new hypothesis
Characteristic | Two compartment tumour model | Non-cancerous LFS host |
|---|---|---|
Senescent Fibroblasts | ✓ | ✓ |
High Oxidative Stress | ✓ | ✓ |
Loss of Stromal Cav-1 | ✓ | ✓ |
Tumour Cells Resistant to Autophagy | ✓ | ✓ |