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Table 1 Characteristics of accelerated host aging in tumours and in the non-cancerous LFS host

From: Li Fraumeni syndrome, cancer and senescence: a new hypothesis

Characteristic Two compartment tumour model Non-cancerous LFS host
Senescent Fibroblasts
High Oxidative Stress
Loss of Stromal Cav-1
Tumour Cells Resistant to Autophagy