Effect of paclitaxel and SB-T-1216 (0.3-3000 nM) on the growth and survival of SK-BR-3 and MCF-7 cells. Control cells (C) were incubated without taxane. The cells were seeded at 20×103 cells/100 µl of medium per well. The number of cells of the inoculum is shown as a dotted line. The number of living cells was determined after 96 h of incubation (see “Materials and Methods“). Each column represents the mean of 8 separate cultures ± SEM.