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Figure 8 | Cancer Cell International

Figure 8

From: 3,4-dihydroxyphenyl acetic acid and (+)-epoxydon isolated from marine algae-derived microorganisms induce down regulation of epidermal growth factor activated mitogenic signaling cascade in Hela cells

Figure 8

Inhibition of the activity of signal molecules in mitogenic signaling cascade. The compounds inhibited EGF-induced phosphorylation of EGFR and its downstream signal molecules in mitogenic signaling. HeLa cells were treated with each compound (50 μg/mL for 40 min) followed by exposure to EGF (10 ng/mL for 10 min) except for the negative control (untreated). Proteins from the cells were resolved by 12% SDS-PAGE and immunoblotted with indicated antibodies. GAPDH was used as an internal loading control.

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