Growth inhibition of DLBCL cell lines by TSA. (A) DoHH2, (B) LY1 and LY8 cells were treated with the indicated concentrations of TSA for 48 h to examine dose-dependent inhibitory effects. Probit Regression determined IC50 values of 45 nM, 250 nM and 350 nM in DoHH2, LY1 and LY8 cells, respectively. (C) Cell growth curves of DoHH2 (treated with 50 nM TSA), (D) LY1 and LY8 cells (treated with 300 nM TSA). Cells treated with DMSO were used as controls. Cell viability of DoHH2, LY1 and LY8 cells was determined by CCK-8 assay. Results are displayed as mean ± SD of three independent experiments performed in triplicate.