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Table 4 Clinical response to R-CHOP therapy according to CD20 Exon2 [216] Polymorphism

From: Single nucleotide polymorphisms of CD20 gene and their relationship with clinical efficacy of R-CHOP in patients with diffuse large B cell lymphoma

  Response

CD20 exon2[216] genotype n (%)

P Value*

 

CC No.(%)

CT + TT No.(%)

  No.(N = 129)

95

34

 

  CR

64(67.4)

16(47.1)

0.091

  PR

22(23.2)

11(32.4)

 

  SD/PD

9(9.4)

7(20.5)

 

  ORR(CR + PR)

86(90.6)

27(79.5)

0.166#1

  CR

64(67.4)

16(47.1)

0.036#2

  Non-CR

31(32.6)

18(52.9)

 
  1. Abbreviations: CR complete response, PR partial response, SD stable disease, PD progressive disease, ORR (OR + PR), overall response, non-CR, PR + SD + PD.
  2. #1 P = 0.166 when comparing ORR with SD/PD;#2 P = 0.036 when comparing CR with non-CR (PR + SD + PD) ;* χ2 test.
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Cancer Cell International

ISSN: 1475-2867

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