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Table 2 Univariate and multivariate analysis of ALDH1A1 phenotype in relation to recurrence-free survival (RFS)

From: Expression of ALDH1 in breast invasive ductal carcinoma: an independent predictor of early tumor relapse

Variable Univariate analysis Multivariate analysis
HR 95% CI P value HR 95% CI P value
ALDH1A1       
 Positive 11.932 4.190–33.977 0.001 11.399 3.776–34.414 0.001
 Negative 1.000    1.000   
ER status       
 Positive 1.013 0.519–1.977 0.970 1.579 0.636–3.921 0.325
 Negative 1.000    1.000   
PR status       
 Positive 0.669 0.345–1.299 0.235 0.568 0.238–1.358 0.203
 Negative 1.000    1.000   
HER2 status       
 Positive 1.307 0.701–2.435 0.400 1.564 0.599–4.085 0.361
Negative 1.000    1.000   
Triple negativity features*     
 Present 0.848 0.441–1.631 0.620 0.808 0.241–2.702 0.729
 Absent 1.000    1.000   
TNM stage       
 Stage III/IV 0.718 0.373–1.382 0.321 0.803 0.402–1.601 0.532
 Stage I/II 1.000    1.000   
Age (years)       
 ≥ 50 0.709 0.376–1.338 0.289 0.803 0.402–1.601 0.532
 < 50 1.000    1.000   
  1. Abbreviations: HR hazard ratio estimated from Cox proportional hazard regression model, CI confidence interval of the estimated HR, ER estrogen receptor, PR progesterone receptor, HER2 human epidermal growth factor receptor 2.
  2. *Immunohistochemically negative for ER, PR, and HER2.