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Table 3 Univariate and multivariate analysis of ALDH1A1 phenotype in relation to distant metastasis-free survival (MFS)

From: Expression of ALDH1 in breast invasive ductal carcinoma: an independent predictor of early tumor relapse

Variable Univariate analysis Multivariate analysis
HR 95% CI P value HR 95% CI P value
ALDH1A1       
 Positive 3.501 1.785–6.866 0.001 3.562 1.790–7.091 0.001
 Negative 1.000    1.000   
ER status       
 Positive 1.111 0.614–2.012 0.727 1.510 0.693–3.290 0.300
 Negative 1.000    1.000   
PR status       
 Positive 0.956 0.546–1.674 0.875 1.052 0.479–2.310 0.900
 Negative 1.000    1.000   
HER2 status       
 Positive 0.969 0.554–1.694 0.911 1.161 0. 540–2.495 0.703
 Negative 1.000    1.000   
Triple negativity features*     
Present 0.870 0.481–1.573 0.645 0.741 0.265–2.073 0.569
 Absent 1.000    1.000   
TNM stage       
 Stage III / IV 1.874 1.010–3.475 0.046 2.248 1.173–4.307 0.015
 Stage I / II 1.000    1.000   
Age (years)       
 ≥ 50 1.399 0.793–2.467 0.247 1.585 0.846–2.970 0.151
 < 50 1.000    1.000   
  1. Abbreviations: HR hazard ratio estimated from Cox proportional hazard regression model, CI Confidence interval of estimated HR. ER estrogen receptor, PR progesterone receptor; HER2 human epidermal growth factor receptor 2.
  2. *Immunohistochemically negative for ER, PR, and HER2.