Figure 1

Heparan sulfate proteoglycans (HSPGs) are primary attachment molecules for entry of Human Papilloma Viruses into cells. Syndecans are cell surface heparan sulfates. Laminin undergoes proteolytic processing and can interact with different cell surface receptors including integrin, syndecan and laminin receptor. CD151 is a member of the tetraspanin group of transmembrane proteins and can interact with different integrin α subunits, including α3, α6, and α7. EGFRs are internalized and there is a prolonged receptor mediated signaling in HPV infected cells. Matrix Metalloproteinases proteolytically cleave bound growth factors and syndecans. These cleaved moieties bind to HPV and this complex can interact with different receptors to gain entry into the cervical cells.