Figure 4
From: Nip the HPV encoded evil in the cancer bud: HPV reshapes TRAILs and signaling landscapes
Shows E7 mediated inhibition of pRB that results in sequestration of E2F. E2F moves into the nucleus to stimulate the expression of miR-15b. E7 also directly represses miR-203 expression. Additionally, p53 triggers expression of miR-145, miR-23b and miR-34a. Therefore E7 indirectly repress the expression of target miRNAs by degrading p53. miRNAs in slanting boxes are over-expressed in cervical cancer cells. Rectangular Boxes indicate post-transcriptional processing of gene subsets bi miRNAs.