Figure 1
From: MiR-214 regulate gastric cancer cell proliferation, migration and invasion by targeting PTEN
Expression of miR-214 and PTEN in gastric cancer cell and tissue specimens. Detection of miR-214 and PTEN mRNA by qRT-PCR using U6 snRNA for normalization. Both SGC-7901 and BGC-823 cells express higher levels of miR-214 compared with normal gastric mucosa epithelial cell lines GES-1 (A), the expression of miR-214 in gastric cancer tissues is higher than that in normal gastric mucosa tissues (B). Whereas, the expression of PTEN mRNA in gastric cancer tissues is lower than that in normal gastric mucosa tissues (C), in addition, we found an inverse correlation between the expression of miR-214 and the level of PTEN mRNA in gastric cancer tissues, but not in normal tissues (D, E). Kaplan-Meier survival curves for 120 gastric cancer cases, low expression of miR-214 (red) was defined as long survival, and high expression (green) was defined as short survival (F). *P < 0.05; **P < 0.01.