Candidate microRNA biomarkers in human epithelial ovarian cancer: systematic review profiling studies and experimental validation

Table 3 The differentially expressed miRNAs (n = 10) with an consistent direction between two studies

miRNAs name	Chromosomal localization	Pre-miRNA length	Mature sequence	Direction of expression	Potential target	Reference
miR 182	7q32.2	110 nt	23∣5′-UUUGGCAAUGGUAGAACUCACACU-3′∣46	↑	NRCAM; RGS17	[8]
				↑		[14]
miR 16	13q14.2	89 nt	14∣5′-UAGCAGCACGUAAAUAUUGGCG-3′∣35	↑	UNC80; KIF21A	[9]
				↑		[13]
miR 29c	1q32.2	88 nt	54∣5′-UAGCACCAUUUGAAAUCGGUUA-3′∣75	↑	COL3A1	[13]
				↑		[11]
miR 224	Xq28	81 nt	8∣5′-CAAGUCACUAGUGGUUCCGUU-3′∣28	↓	CDADC1; UBXN4	[8]
				↓		[10]
miR 125b	11q24.1	88 nt	15∣5′-UCCCUGAGACCCUAACUUGUGA-3′∣36	↓	CSNK2A1; FAM169B	[9]
				↓		[12]
miR 127	14q32.2	97 nt	23∣5′-CUGAAGCUCAGAGGGCUCUGAU-3′∣44	↓	NEK1	[8]
				↓		[10]
Let-7a	9q22.32	80 nt	6∣5′-UGAGGUAGUAGGUUGUAUAGUU-3′∣27	↓	C14orf28; HMGA2	[12]
				↓		[10]
Let-7c	21q21.1	84 nt	11∣5′-UGAGGUAGUAGGUUGUAUGGUU-3′∣32	↓	C14orf28; HMGA2	[10]
				↓		[12]
Let-7b	22q13.31	83 nt	6∣5′-UGAGGUAGUAGGUUGUGUGGUU −3′∣27	↓	C14orf28; HMGA2	[9]
				↓		[12]
miR 125a	19q13.41	86 nt	15∣5′-UCCCUGAGACCCUUUAACCUGUGA −3′∣38	↓	CSNK2A1; ZNF543	[9]
				↓		[10]

ISSN: 1475-2867