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Figure 1 | Cancer Cell International

Figure 1

From: Low-dose etoposide-treatment induces endoreplication and cell death accompanied by cytoskeletal alterations in A549 cells: Does the response involve senescence? The possible role of vimentin

Figure 1

Activity of senescence-associated ß-galactosidase in A549 cells after treatment with etoposide - statistical data from light microscopic examinations. Incubation with increasing concentrations of the drug (0.5, 0.75, 1, 1.5, 2, 3 and 6 μM etoposide) for 72 h was followed by further 24 h of incubation in fresh medium. The activity of the enzyme was detected at pH 6. Very highly statistically significant differences as compared to the control cells are marked by asterisks (Cochran–Cox statistics, P<0.001). Results are representative of ten independent experiments.

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