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Figure 16 | Cancer Cell International

Figure 16

From: Low-dose etoposide-treatment induces endoreplication and cell death accompanied by cytoskeletal alterations in A549 cells: Does the response involve senescence? The possible role of vimentin

Figure 16

a-d Localization of G-actin in A549 cells after treatment with etoposide - fluorescence microscopic examination (labeling with DNase I). a Control cells, b 0.75 μM etoposide, c 1.5 μM etoposide, d 3 μM etoposide. Visible aggregation of G-actin in the perinuclear area after the treatment, as well as an increased number of G-actin-positive dot-like and vesicle-like structures in the cytoplasm. The intense fluorescence patterns indicative of cells with DNA fragmentation. Nuclei were counterstained with DAPI. Results are indicative of five independent experiments. Bar 50 μm.

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Cancer Cell International

ISSN: 1475-2867

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