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Figure 4 | Cancer Cell International

Figure 4

From: Inhibition of tumor promoting signals by activation of SSTR2 and opioid receptors in human breast cancer cells

Figure 4

Tumor suppressor proteins PTEN and p53 are modulated in cell and receptor specific manner in tumor cells. Representative immunoblots showing the effect of SSTR2 or ORs activation on the expression of PTEN (A) and p53 (B) in MCF-7, MDA-MB231 and T47D cells respectively. (A) The expression of PTEN is enhanced in MCF-7 as well as T47D cells; however the MDA-MB231 cells displayed no discernible changes in the levels of PTEN. (B) The expression of p53 was in a receptor and cell-specific manner. Note the comparable changes in PTEN and p53 expression in MCF-7 and T47D cells. Histograms illustrate densitometric analysis of PTEN and p53 levels using tubulin as the loading control. The results presented here are representation of mean ± SEM, n = 3. Significant difference was considered at *p < 0.05 vs. control.

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