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Figure 1 | Cancer Cell International

Figure 1

From: The in vitro influences of epidermal growth factor and heregulin-β1 on the efficacy of trastuzumab used in Her-2 positive breast adenocarcinoma

Figure 1

Cell viability in MCF-7 and SK-Br-3 cells. Mean (± SEM) cell viability determined using a tetrazolium conversion assay. Cells were first exposed to trastuzumab ranging from 1 μg/ml to 500 μg/ml. The result was a reduction in cell viability in SK-Br-3 cells which was not seen in MCF-7 cells. Cells were then exposed to a saturating concentration of trastuzumab combined with either EGF (400 ηg/ml) or HRG-β1 (200 ηg/ml). These endogenous biological molecules significantly abrogated cell viability observed for trastuzumab (Table1).

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