Table 1 Univariate analysis of overall survival following resection for ICC (n = 81)
Clinical factor | N | Survival rate (%) | Median survival (months) | P-value (log-rank) | |
|---|---|---|---|---|---|
1-year | 3-year | ||||
Gender | 0.608 | ||||
Male | 48 | 39.6% | 9.2% | 10 | |
Female | 33 | 48.5% | 13.9% | 12 | |
Age | 0.108 | ||||
≤ 60 years | 43 | 48.8% | 15.2% | 12 | |
> 60 years | 38 | 36.8% | 6.3% | 7 | |
Intrahepatic duct stones | 0.277 | ||||
Yes | 13 | 53.8% | 15.4% | 26 | |
No | 68 | 41.5% | 10.7% | 10 | |
Serum hepatitis index | 0.017 | ||||
HBsAg or anti-HBc | 37 | 45.9% | 15.0% | 12 | |
anti-HBs + | 21 | 52.4% | 16.3% | 13 | |
All - | 23 | 30.4% | 0% | 6 | |
ALT | 0.068 | ||||
≤ 40 U/L | 45 | 53.3% | 13.2% | 13 | |
> 40 U/L | 36 | 31.6% | 9.8% | 10 | |
CA19-9 | 0.015 | ||||
≤ 200 U/ml | 34 | 50.0% | 19.1% | 12 | |
> 200 U/ml | 47 | 38.3% | 5.1% | 8 | |
GGT | 0.008 | ||||
≤ 64 U/L | 23 | 60.9% | 19.1% | 16 | |
> 64 U/L | 58 | 36.2% | 7.9% | 9 | |
Total bilirubin | 0.124 | ||||
≤ 20 μmol/L | 52 | 48.0% | 13.6% | 12 | |
> 20 μmol/L | 29 | 34.5% | 6.9% | 9 | |
Alkaline phosphatase | 0.01 | ||||
≤ 119 U/L | 30 | 60.0% | 16.2% | 15 | |
> 119 U/L | 51 | 33.3% | 7.8% | 8 | |
Lymphatic metastasis | 0.005 | ||||
Yes | 50 | 34.0% | 6.0% | 6 | |
No | 31 | 58.1% | 20.2% | 15 | |
Operative procedure | 0.021 | ||||
Radical | 60 | 45.0% | 14.2% | 12 | |
Palliative | 21 | 28.6% | 0 | 5 | |
Intrahepatic metastasis | 0.015 | ||||
Yes | 31 | 29.0% | 6.5% | 6 | |
No | 50 | 52.0% | 13.9% | 13 | |
Diabetes | 0.07 | ||||
Yes | 6 | 16.7% | 0 | 5 | |
No | 75 | 45.3% | 12.0% | 12 | |
Adjuvant chemotherapy | 0.001 | ||||
Yes | 18 | 83.8% | 33.3% | 22 | |
No | 63 | 31.7% | 4.1% | 8 | |