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Figure 6 | Cancer Cell International

Figure 6

From: The antiproliferative effect of C2-ceramide on lung cancer cells through apoptosis by inhibiting Akt and NFκB

Figure 6

Schematic diagram of hypothesized mechanism of C 2 -ceramide-induced apoptosis of lung cancer cells. C2-ceramide inhibits the activity of both Akt and NF-κB, causing the down-regulation of pro-survival survivin and cell cycle promoter cyclin A2. On the contrary, C2-ceramide increases the protein level of pro-apoptotic Bax. As a result, C2-creamide treatment causes cell cycle G1 arrest and chromatin condensation, subsequently, triggering the apoptosis of lung cancer cells.

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