Figure 3

Combination Index as a growth inhibitory effect of combination treatment with Herceptin® and anti-cancer agents. a. In the combination of Herceptin and doxorubincin treatment, the synergetic effect was observed in YBC-2 and NCI-N87 cells, but not in YBC-3 cell line. b. In the combination of herceptin and cisplatin, the synergetic effects were observed in SK-BR-3, NCI-N87 and YBC-3 cell lines (CI < 1). However, the inhibitory effects were observed in YBC-2 and U-87 MG cell lines (CI > 1). c. The treatment of Herceptin and paclitaxel, in YBC-3 and U-87 MG cell lines, the inhibitory effects were observed (CI > 1), however, in YBC-3 cell line, the synergetic effect was observed (CI < 1). In SK-BR-3 and NCI-87 cell lines, the effects were different depends on the dose of the drugs. d. In the combination of Herceptin and 5-FU, the inhibitory effects were observed in all of the cell lines (CI > 1).