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Figure 7 | Cancer Cell International

Figure 7

From: Sensitization of U937 leukemia cells to doxorubicin by the MG132 proteasome inhibitor induces an increase in apoptosis by suppressing NF-kappa B and mitochondrial membrane potential loss

Figure 7

Expression of pro- and antiapoptotic genes in U937 human leukemic cells treated with Doxorubicin (DOX), MG132, and MG132 + DOX. U937 human leukemia cells were incubated, alone or in combination, with DOX 1 μM, MG132 (1 μM), or MG132 + DOX for 3 h. Gene expression was assessed by quantitative real-time PCR. Data are expressed as relative mRNA fold-change. RPL32 were used for normalization, and the value of untreated cells, as calibrator. Variations were considered significant at ≥30% compared with the constitutive gene. In all cases, the Standard deviation (SD) was not >0.08.

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