Figure 4

Effect of T0901317 on melanoma growth in C56BL/6 mice. (A) B16F10 melanoma cells (10⁶) were injected subcutaneously into flanks of the mice. The liver X receptor agonist T0901317 (10 mg/kg) or sesame oil vehicle was administered by daily oral gavage. Tumor growths were monitored every 3 days. (B) Expressions of LXRs target genes (ABCA1 and SREBF1) in tumor samples were analyzed by real-time PCR at day 15 when mice were sacrificed. ^*P < 0.05, ^**P < 0.01.