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Figure 5 | Cancer Cell International

Figure 5

From: An eEF1A1 truncation encoded by PTI-1 exerts its oncogenic effect inside the nucleus

Figure 5

Foci formation at 5% serum. NIH 3 T3 cells were stably transfected with the indicated constructs. Three sets of cell lines were independently established and analyzed for each construct. (A) shows the number of foci counted in the various cell lines, while (B) and (C) depict representative examples of background growth and foci growth, respectively. In A, standard deviations are shown. The construct expressing the full-length PTI-1 mRNA with a mutation in the start codon of ORF1 is clearly transforming (a comparison of the number of foci obtained for the pZeoSV2-PTI-1-FL-ΔATG and empty pZeoSV2 in a Student's t-test results in a P value of 0.024).

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