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Table 3 Impact of non-synonymous* (coding) substitutions on the ATPase6 and 8 genes

From: The mitochondrial ATPase6 gene is more susceptible to mutation than the ATPase8 gene in breast cancer patients

Non-synonymous coding substitutions

Damaging score

Benign score

ATPase 6 gene

T8542C( F6L)

0.976

0.917

G8557A (A11T)

0.002

0.004

T8567C (I14T)

0.617

0.280

G8572A (G16S)

0.895

0.498

C8684T (T53I)

0.005

0.005

A8701G (T59A)

0.002

0.005

C8794T (H90Y)

0.002

0.003

A8860G (T112A)

0.000

0.003

T8881C (S119P)

0.325

0.149

G8950A (V142I)

0.000

0.001

A9007G (T161A)

0.994

0.988

A9041G H(172R)

0.854

0.331

G9055A (A177T)

0.854

0.331

ATPase 8 gene

A8384G (T7A)

0.845

0.399

T8542C (S68P)

0.000

0.000

  1. Non-synonymous variants were predicted as damaging and benign (With a score of 0 to 1) based on effects on the resulting protein using PolyPhen-2 software.
  2. The new variants are in bold format.