The impact of COX-2 on invasion of osteosarcoma cell and its mechanism of regulation

Table 1 The influence of COX-2 antisense oligonucleotides on osteosarcoma cell invasion $(\bar{x} \pm s)$

The concentration of COX-2-ASOND (nmol/L)	Penetrating cells (× 200)	Invasion inhibition rate %	P value
Blank	34.42 ± 4.78	0	-
Control	31.65 ± 5.81	9.43 ± 2.72	>0.05
50	26.56 ± 3.45	22.85 ± 7.12	<0.05
100	23.26 ± 4.66	32.42 ± 10.26	<0.05
200	17.54 ± 3.36	53.47 ± 9.35	<0.05
400	12.75 ± 3.22	64.67 ± 8.66	<0.01
800	11.86 ± 2.85	67.22 ± 7.52	<0.01

Note: Levene statistics was used to confirm the homogeneity of variance between the experimental groups. One-way ANOVA with Bonferroni correction of p-values was used for the movement inhibition ratio.

ISSN: 1475-2867