Skip to main content

Table 1 Associations between NKX2-8 expression levels and clinicopathologic parameters of HCC

From: Decreased expression of the Nkx2.8 gene correlates with tumor progression and a poor prognosis in HCC cancer

Variables NKX2-8 mRNA expression P NKX2-8 protein expression P
Low High Negative Positive
(n = 20) (n = 28) (n = 26) (n = 22)
Gender
Female 3 4 0.572 3 4 0.615
Male 17 24   23 18  
Age
≤50 11 13 0.734 14 9 0.643
>50 9 15   9 13  
Preoperative AFP (ng/mL)
≤20 7 12 0.126 11 8 0.263
>20 13 16   15 14  
Liver cirrhosis
No 4 8 0.101 3 9 0.092
Yes 16 20   23 13  
Tumor diameter (cm)
≤5 14 21 0.164 17 18 0.076
>5 6 7   9 4  
Tumor encapsulation
None 11 13 0.375 11 13 0.469
Complete 9 15   9 9  
Clinical TNM stage
I-II 14 23 0.032* 17 20 0.026*
III-IV 6 5   9 2  
  1. One-way Analysis of Variance (ANOVA) test was performed.
  2. *Indicate a significant difference (P < 0.05) by Student’s t-test.