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Table 2 Associations between the G1790A polymorphism and cancer risk

From: The association between hypoxia-inducible factor-1 α gene G1790A polymorphism and cancer risk: a meta-analysis of 28 case–control studies

Varibles AA + AG VS GG AA VS AG + GG AA VS GG AG VS GG
na OR (95% CI) P b na OR (95% CI) P b na OR (95% CI) P b na OR (95% CI) P b
Overall 25 1.85 (1.27-2.69 ) 0 26 5.69 (3.87-8.37) 0 12 6.63 (4.49-9.79) 0 11 2.39 (1.53-3.75) 0
Overall for HWE c 22 1.82 (1.27-2.59) 0 10 7.01 (4.42-11.09) 0 10 7.75 (4.87-12.34) 0 10 3.4 (2–5.8) 0
cancer cite             
Prostate cancer 3 1.41 (0.93-2.14) 0.1 1 3.24 (0.13-79.9) 0.47 1 3.34 (0.13-82.30) 0.46 1 1.98 (0.07-50.4) 0.67
Head and neck cancer 6 3.57 (0.98-12.99) 0.05 3 58 (1.75-1924.88) 0.02 3 101.38 (22.09-65.29) 0 3 12.53 (2.42-64.76) 0
Pancreatic cancer 2 2.5 ( 0.93-6.72) 0.06 1 18.8 (0.96-371.55) 0.05 1 18.3 (0.93-360.19) 0.05 1 29.4 (1.12-772.37) 0.04
Lung cancer 3 2.14 ( 1.56-2.95) 0 2 4.5 (2.3-8.81) 0 2 5.42 (2.74-10.7) 0 2 3.02 (1.48-6.16) 0
Renal cell carcinoma 3 0.94 ( 0.16-5.29) 0.95 2 2.69 (1.20-6.03) 0.01 2 3.71 (1.72-7.99) 0.46 1 0.81 (0.33-2) 0.65
Other cancer 5 2.11 ( 1.03-4.32) 0.45 1 0.35 (0.01-8.80) 0.53 1 0.35 (0.01-8.8) 0.52 1 0.36 (0.01-9.68) 0.54
Breast cancer 3 0.63 ( 0.19-2.08) 0 2 1.44 (0.34-6.08) 0.62 2 1.43 (0.37-5.44) 0.59 2 1.45 (0.34-6.17) 0.61
Subgroup by ethnicity             
Asian 13 1.75 (1.3-2.37) 0 7 3.37 (1.94-5.86) 0 7 3.82 (2.19-6.66) 0 7 2.41 (1.31-4.43) 0
Caucasian 9 1.12 (0.41-3.03) 0.81 4 3.74 (1.85-7.54) 0 4 5.05 (2.53-10.07) 0 3 2.66 (0.33-21.23) 0.35
control source             
PB 22 1.95 (1.33-2.85) 0 11 5.9 (4.0-8.8) 0 11 7.2 (4.79-10.82) 0 11 2.39 (1.53-3.75) 0
HB 3 0.39 (0.01-9.90) 0.56 1 0.88 (0.04-16.82) c 0.93 1 0.44 (0.02-8.53) 0.59 0 No statistics  
Gender             
Female 5 0.92 (0.46-1.84) 0.82 3 1.11 (0.34-3.66) 0.85 3 1.13 (0.34-3.7) 0.83 3 1.13 (0.31-4.02) 0.84
Male 3 1.41 (0.93-2.14) 0.1 1 3.24 (0.13-79.9) 0.47 1 3.34 (0.13-82.3) 0.46 1 1.98 (0.07-50.4) 0.67
  1. aNumber of comparisons.
  2. bP value of Q-test for heterogeneity test.
  3. cData after excluding those studies’ controls not in Hardy-Weinberg equilibrium.