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Table 2 Genotype and allele frequencies of the COX-2 polymorphisms among the cases and controls and the associations with risk the breast cancer

From: Functional promoter -765 G > C variant in COX-2 gene is associated with the susceptibility of breast cancer in Chinese Han women

Polymorphisms Case (N = 465) Control (N = 799) P* OR (95% CI)
  N % N %   
-765 G > C       
 GG 394 84.7 719 90.0 0.021 1.00 (reference)
 GC 67 14.4 76 9.6   1.55 (1.09–2.20)
 CC 4 0.9 4 0.4   1.88 (0.47–7.65)
 GG 394 84.7 719 90.0 0.005 1.00 (reference)
 GC + CC 71 15.3 80 10.0   1.56 (1.11–2.21)
 C 75 8.0 84 5.2 0.005  
8473 C > T       
 TT 299 64.3 515 64.5 0.209 1.00 (reference)
 TC 132 28.4 244 30.5   0.93 (0.72–1.21)
 CC 34 7.3 40 5.0   1.46 (0.90–2.37)
 TT 299 64.3 515 64.5   1.00 (reference)
 TC + CC 166 35.7 284 35.5 0.956  
 C 200 21.5 324 20.3 0.462  
  1. CI, confidence interval; OR, odds ratio; Compared with individuals with COX-2 -765 GG genotype, individual with GC or GC/CC genotypes both had a significantly increased susceptibility to breast cancer. *Two-sided χ2 test for the distributions of genotype and allele frequencies.
  2. Adjusted for age and age at menarche.