Table 2 Genotype and allele frequencies of the COX-2 polymorphisms among the cases and controls and the associations with risk the breast cancer
Polymorphisms | Case (N = 465) | Control (N = 799) | P* | OR (95% CI)† | ||
|---|---|---|---|---|---|---|
N | % | N | % | |||
-765 G > C | ||||||
GG | 394 | 84.7 | 719 | 90.0 | 0.021 | 1.00 (reference) |
GC | 67 | 14.4 | 76 | 9.6 | 1.55 (1.09–2.20) | |
CC | 4 | 0.9 | 4 | 0.4 | 1.88 (0.47–7.65) | |
GG | 394 | 84.7 | 719 | 90.0 | 0.005 | 1.00 (reference) |
GC + CC | 71 | 15.3 | 80 | 10.0 | 1.56 (1.11–2.21) | |
C | 75 | 8.0 | 84 | 5.2 | 0.005 | |
8473 C > T | ||||||
TT | 299 | 64.3 | 515 | 64.5 | 0.209 | 1.00 (reference) |
TC | 132 | 28.4 | 244 | 30.5 | 0.93 (0.72–1.21) | |
CC | 34 | 7.3 | 40 | 5.0 | 1.46 (0.90–2.37) | |
TT | 299 | 64.3 | 515 | 64.5 | 1.00 (reference) | |
TC + CC | 166 | 35.7 | 284 | 35.5 | 0.956 | |
C | 200 | 21.5 | 324 | 20.3 | 0.462 | |