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Table 3 Stratification analyses on age between the COX-2 -765 G > C polymorphism and risk of breast cancer

From: Functional promoter -765 G > C variant in COX-2 gene is associated with the susceptibility of breast cancer in Chinese Han women

The-765 G > C genotypes

Case (N = 465)

Control (N = 799)

P*

OR (95% CI)†

 

N

%

N

%

  

Age < 52

      

GG

204

85.4

395

90.4

0.049

1.00 (reference)

GC + CC

35

14.6

42

9.6

 

1.61 (1.00–2.61)

Age ≥ 52

      

GG

190

84.1

324

89.5

0.053

1.00 (reference)

GC + CC

36

15.9

38

10.5

 

1.60 (0.96–2.68)

  1. CI, confidence interval; OR, odds ratio. The risk effect of the -765 G > C variant genotypes (GC/CC) were more pronounced in younger subjects rather than old subjects. *Two-sided χ2 test for the distributions of genotype frequencies. †Adjusted for age and age at menarche.
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Cancer Cell International

ISSN: 1475-2867

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