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Table 3 Stratification analyses on age between the COX-2 -765 G > C polymorphism and risk of breast cancer

From: Functional promoter -765 G > C variant in COX-2 gene is associated with the susceptibility of breast cancer in Chinese Han women

The-765 G > C genotypes Case (N = 465) Control (N = 799) P* OR (95% CI)
  N % N %   
Age < 52       
GG 204 85.4 395 90.4 0.049 1.00 (reference)
GC + CC 35 14.6 42 9.6   1.61 (1.00–2.61)
Age ≥ 52       
GG 190 84.1 324 89.5 0.053 1.00 (reference)
GC + CC 36 15.9 38 10.5   1.60 (0.96–2.68)
  1. CI, confidence interval; OR, odds ratio. The risk effect of the -765 G > C variant genotypes (GC/CC) were more pronounced in younger subjects rather than old subjects. *Two-sided χ2 test for the distributions of genotype frequencies. Adjusted for age and age at menarche.