Figure 2

Results of gene cluster analysis after the expression profiling of treated cells. The genes were clustered according to the type of changes in the expression in the respective cell line (Daoy or D283 Med) after the combined treatment with ATRA and inhibitors (CA or CX). The cells were treated with ATRA alone or in combination with CA (an inhibitor of 5-LOX) or CX (an inhibitor of COX-2); numbers indicate the concentration in μM. The green color at the farthest left end of the color scale corresponds to the minimal value; the red color at the farthest right end of the color scale corresponds to the maximal value; the black color in the middle corresponds to the average value. Each of the other values corresponds to a certain color according to its magnitude. The colors are assigned according to the value of the particular gene expression in all samples in the respective experimental variant (I, II, III or IV). Genes discussed in the text in detail are highlighted by red dots.