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Figure 5 | Cancer Cell International

Figure 5

From: Decrease expression of microRNA-744 promotes cell proliferation by targeting c-Myc in human hepatocellular carcinoma

Figure 5

miR-744 inhibits c-Myc-dependent activity and cell proliferation in HCC cells. (A, B) miR-744 inhibits c-Myc-dependent transcription of the c-Myc target gene Cyclin D1. HepG2 and SMMC-7721 cells were transfected with miR-744 and/or pGL3-c-Myc, and the expression of c-Myc and Cyclin D1 were analyzed by Western blotting. The value up each lane indicates the protein expression with β-actin as an internal control. (C, D) miR-744 inhibits c-Myc-dependent cell proliferation. HepG2 and SMMC-7721 cells were transfected with miR-744 and/or pGL3-c-Myc, and cells proliferation was measured by CCK-8 analysis. The data were subjected to Student's t-test. *p < 0.05.

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