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Figure 6 | Cancer Cell International

Figure 6

From: Anti-tumor effect of ribavirin in combination with interferon-α on renal cell carcinoma cell lines in vitro

Figure 6

IFN-α alone, ribavirin alone, or a combination of IFN-α and ribavirin inhibit IL-10 production, but increase TGF-β secretion in Renca and 786–0 cells. (A) IL-10 levels after treatment with ribavirin (100–1000 μM) or a combination of IFN-α and ribavirin. (B) Levels of IL-10 after treatment with IFN-α (20–1000 IU/ml) or a combination of IFN-α and ribavirin. (C) Levels of TGF-β after treatment with ribavirin (100–1000 μM) or a combination of IFN-α and ribavirin. (D) Levels of TGF-β after treatment with IFN-α (20–1000 IU/ml) or a combination of IFN-α and ribavirin. C1: combination of 500 IU/ml of IFN-α and 500 μM ribavirin. C2: 1000 IU/ml of IFN-α and 1000 μM ribavirin. The suppression was significant within the range of 20–1000 IU/ml of IFN-α or in the range of 100–1000 μM ribavirin (*indicates a significant difference in comparison with controls).

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