Figure 5

Effect of isomorellin, forbesione and/or doxorubicin on protein expression in cholangiocarcinoma cell lines. A and C, KKU-M156 cells treated with DMSO or indicated concentrations of isomorellin and/or doxorubicin; B and D, KKU-100 cells treated with DMSO or indicated concentrations of forbesione and/or doxorubicin for 48 h. Protein expression of nuclear factor-κB (NF-κB), inhibitor of NF-κB (IκB-α), phosphorylated IκB-α (pIκB-α) and multidrug resistance-associated protein 1 (MRP1) was determined by Western blot analysis.