Table 3 Fold-change of proteins in isomorellin- and/or doxorubicin-treated cells vs. DMSO-treated KKU-M156 cells

Isomorellin

0.06

0.12

0.25

Doxorubicin

0.007

0.015

0.031

Iso + Dox

C1

C2

C3

Bcl-2

Isomorellin

0.83^a

0.83^a

0.76^a

Doxorubicin

1.00

0.95

0.82^a

Iso + Dox

0.84^a

0.80^b,–,*

0.41^c,*,*

Bax

Isomorellin

1.26

1.32^c

1.32^c

Doxorubicin

1.20

1.33^c

1.45^c

Iso + Dox

1.84^b

1.93^c,*,*

2.13^c,*,*

Bax/Bcl-2

Isomorellin

0.48^c

0.50^b

0.50^b

Doxorubicin

0.35^c

0.40^b

0.51^b

Iso + Dox

0.62^c

1.09^–,*,*

2.35^c,*,*

Survivin

Isomorellin

1.00

0.96

0.86

Doxorubicin

0.96

0.96

0.95

Iso + Dox

0.96

0.64^b,*,*

0.02^c,*,*

Procaspase-9

Isomorellin

0.88

0.84

0.74^a

Doxorubicin

0.87

0.82

0.76^a

Iso + Dox

0.82^a

0.57^b,*,*

0.39^b,*,*

Activated

Isomorellin

10.00^c

18.00^c

30.00^c

caspase-9 

Doxorubicin

10.00^c

20.00^c

24.00^c

Iso + Dox

20.00^c

64.00^c,*,*

73.00^c,*,*

Procaspase-3

Isomorellin

1.00

0.93

0.84

Doxorubicin

1.00

0.93

0.86^a

Iso + Dox

0.93

0.68^a,*,*

0.67^b,*,*

Activated

Isomorellin

8.00^c

10.00^c

20.00^c

caspase-3

Doxorubicin

8.00^c

9.00^c

12.00^c

Iso + Dox

1.00

32.00^c,*,*

36.00^c,*,*

IκB-α

Isomorellin

1.16^a

1.18

1.25^b

Doxorubicin

1.16^a

1.17

1.21^b

Iso + Dox

1.17

1.21

1.40^a,*,*

pIκB-α

Isomorellin

0.93

0.87

0.02^a

Doxorubicin

0.96

0.78

0.02^b

Iso + Dox

0.85^a

0.73^a,*,–

0.02^b

NF-κB/p65

Isomorellin

1.00

0.77^a

0.01^c

Doxorubicin

1.00

1.00

0.87^a

Iso + Dox

0.66^b

0.02^c,*,*

0.01^c,–,*

MRP1

Isomorellin

0.97

0.91

0.79^b

Doxorubicin

0.97

0.96

0.57^b

Iso + Dox

0.81^a

0.79^a,–,*

0.35^c,*,*