Table 4 Fold-change of proteins in forbesione- and/or doxorubicin-treated vs. DMSO-treated KKU-100 cells

Forbesione

0.25

0.50

1.00

Doxorubicin

0.006

0.012

0.025

Forb + Dox

C1

C2

C3

Bcl-2

Forbesione

0.63^a

0.60^a

0.27^c

Doxorubicin

0.76

0.68^b

0.25^c

Forb + Dox

0.74^a

0.65^b,–,*

0.10^c,*,*

Bax

Forbesione

1.56^a

2.06^b

2.06^c

Doxorubicin

1.87^a

2.07^a

2.17^a

Forb + Dox

2.35^c

2.37^c,*,*

3.24^c,*,*

Bax/Bcl-2

Forbesione

0.53^b

0.73^a

1.63^c

Doxorubicin

0.84^a

1.03

2.87^c

Forb + Dox

1.18

1.35^a,*,–

12.00^c,*,*

survivin

Forbesione

0.96

0.78^a

0.35^c

Doxorubicin

1.00

0.97

0.24^c

Forb + Dox

0.97

0.41^a,*,*

0.13^c,*,*

Procaspase-9

Forbesione

0.92

0.79^a

0.70^a

Doxorubicin

0.90

0.71^a

0.65^a

Forb + Dox

0.69

0.68

0^c,*,*

Activated

Forbesione

10.00^c

39.00^c

42.00^c

caspase-9 

Doxorubicin

22.00^c

48.00^c

51.00^c

Forb + Dox

50.00^c

50.00^c,*,–

64.00^c,*,*

Procaspase-3

Forbesione

1.00

0.99

0.76^a

Doxorubicin

0.98

0.76

0.69^a

Forb + Dox

0.97

0.74^a,*,–

0^c,*,*

Activated

Forbesione

9.00^c

9.00^c

42.00^c

caspase-3

Doxorubicin

20.00^c

40.00^c

50.00^c

Forb + Dox

15.00^c

47.00^c,*,–

54.00^c,*,*

IκB-α

Forbesione

1.05

1.07

1.15

Doxorubicin

1.03

1.06

1.12

Forb + Dox

1.16^a

1.21^b,–,*

1.21^b,*,*

pIκB-α

Forbesione

0.97

0.97

0.14^b

Doxorubicin

0.58^a

0.58^a

0.14^b

Forb + Dox

0.25^c

0.01^c,*,*

0.01^c,*,*

NF-κB/p65

Forbesione

1.00

0.78^b

0.12^b

Doxorubicin

1.00

1.00

1.00

Forb + Dox

0.95

0.01^c,*,*

0.01^c,*,*

MRP1

Forbesione

0.89^a

0.79^a

0.71^a

Doxorubicin

1.00

0.96

0.82^a

Forb + Dox

0.75^a

0.74^b,–,*

0.34^c,*,*