TY - JOUR AU - Hardman, W. Elaine AU - Munoz, Jesus AU - Cameron, Ivan L. PY - 2002 DA - 2002/07/17 TI - Role of lipid peroxidation and antioxidant enzymes in omega 3 fatty acids induced suppression of breast cancer xenograft growth in mice JO - Cancer Cell International SP - 10 VL - 2 IS - 1 AB - Supplementing mice with high levels of dietary n-3 polyunsaturated fatty acids (PUFAs) increases the n-3 PUFAs in cell membranes, increases the susceptibility of the cells for lipid peroxidation (LPO) and decreases the growth rate of mammary and other tumors. However, the results of an earlier study indicated that a factor in addition to LPO was involved in the reduction in tumor growth in n-3 PUFAs fed mice. Athymic mice bearing MDA-MB-231 human breast carcinoma xenografts, were fed fish oil concentrate (FOC) or control diets, with and without supplemental Vitamin E (2000 IU /kg diet) and were sacrificed both before and after doxorubicin (DOX) treatment to evaluate factors involved in tumor growth suppression. SN - 1475-2867 UR - https://doi.org/10.1186/1475-2867-2-10 DO - 10.1186/1475-2867-2-10 ID - Hardman2002 ER -