Skip to main content

Table 1 The ratio of n-3 to n-6 fatty acids in the microsomal or mitochondrial membranes of liver, colon or tumor in mice fed a diet containing either 5% corn oil (CO) or 3% fish oil concentrate (FOC) and 2% CO with or without 2000 IU/kg Vitamin E for two weeks. Two way ANOVA revealed that consumption of supplemental Vitamin E did not effect the fatty acid composition thus ratios due to dietary fat are shown. Mean ± SEM, (n).

From: Role of lipid peroxidation and antioxidant enzymes in omega 3 fatty acids induced suppression of breast cancer xenograft growth in mice

Tissue

Fraction

5% CO

3% FOC/2% COa

Fold difference

Liver

Microsomal

0.06 ± 0.02 (8)

1.11 ± 0.18 (7)

18.5

 

Mitochondrial

0.09 ± 0.02 (8)

0.77 ± 0.08 (7)

8.6

Colon

Microsomal

0.18 ± 0.09 (8)

0.62 ± 0.15 (7)

3.4

 

Mitochondrial

0.24 ± 0.09 (8)

0.59 ± 0.24 (7)

2.5

Tumor

Microsomal

0.11 ± 0.10 (8)

1.15 ± 0.10 (7)

10.5

 

Mitochondrial

0.59 ± 0.57 (8)

1.32 ± 0.37 (7)

2.2

  1. a The n-3 to n-6 ratio was significantly higher in every tissue fraction of mice that consumed the FOC diet than in mice that consumed the CO diet.