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Table 3 Thiobarbituric acid reactive substances (TBARS, nmols/mg protein, mean ± SE) in the tumors, livers and colons of groups of mice fed diets containing either 5% CO or 3% FOC and 2% CO with or without 2000 IU Vitamin E/kg diet for two weeks. Some mice were sacrificed 24 h after one injection of DOX (5 mg/kg body weight, i.v.).

From: Role of lipid peroxidation and antioxidant enzymes in omega 3 fatty acids induced suppression of breast cancer xenograft growth in mice

Diet type

n

TBARS before DOX

n

TBARS after DOX

Tumor

5% CO

4

0.59 ± 0.30cd

3

0.79 ± 0.12cd

5% CO + E

5

0.53 ± 0.05cd

4

0.59 ± 0.21cd

3% FOC

4

1.09 ± 0.14bc

3

1.46 ± 0.29b

3% FOC + E

3

0.38 ± 0.15d

4

2.37 ± 0.37a

Liver

5% CO

4

1.09 ± 0.38b

3

0.98 ± 0.06b

5% CO + E

5

0.69 ± 0.10b

5

0.71 ± 0.09b

3% FOC

4

1.77 ± 0.19a

4

1.99 ± 0.31a

3% FOC + E

3

0.61 ± 0.08b

4

0.60 ± 0.08b

Colon

5% CO

3

2.58 ± 0.47a

3

1.21 ± 0.57a

5% CO + E

4

2.10 ± 1.72a

5

1.00 ± 0.48a

3% FOC

4

3.40 ± 1.13a

4

2.59 ± 1.01a

3% FOC + E

3

2.27 ± 1.22a

5

2.35 ± 0.77a

  1. a,b,c,d One way ANOVA followed by an SNK multiple comparison test indicated that within each tissue type the mean TBARS of each group that share a superscript were not significantly (p < 0.05) different.