Table 2 Effect of various polylysines on K-562 cell cultures Cell number: × 103 /ml culture medium (average ± SD)
Compound | SZTP-14 | SZTP-15 | ||||||
|---|---|---|---|---|---|---|---|---|
dose (μg/ml) | Control | 1 | 10 | 100 | Control | 1 | 10 | 100 |
Hours after treatment 24 | 120 ± 10 | 93.3 ± 11 | 90 ± 20 | 0 | 120 ± 15 | 100 ± 11 | 60 ± 15 | 50 ± 15 |
48 | 223.3 ± | 156.6 ± 5 | 83.3 ± 5 | 0 | 190 ± 11 | 140 ± 15 | 120 ± 19 | 20 ± 5 |
72 | 240 ± 17 | 173.3 ± | 136.6 ± 15 | 0 | 250 ± 15 | 190 ± 10 | 110 ± 25 | 10 ± 5 |
Compound | SZTP-16 | SZTP-17 | ||||||
dose (μg/ml) | Control | 1 | 10 | 100 | Control | 1 | 10 | 100 |
Hours after treatment 24 | 130 ± 10 | 120 ± 13 | 120 ± 14 | 120 ± 15 | 150 ± 15 | 130 ± 12 | 120 ± 10 | 120 ± 10 |
48 | 200 ± 15 | 210 ± 20 | 160 ± 17 | 120 ± 10 | 220 ± 18 | 210 ± 16 | 200 ± 17 | 190 ± 14 |
72 | 260 ± 20 | 280 ± 22 | 240 ± 23 | 140 ± 20 | 280 ± 20 | 280 ± 18 | 260 ± 20 | 210 ± 20 |
Compound | SZTO-18 | H-17 | ||||||
dose (μg/ml) | Control | 1 | 10 | 100 | Control | 1 | 10 | 100 |
Hours after treatment 24 | 150 ± 14 | 140 ± 12 | 120 ± 10 | 100 ± 11 | 150 ± 14 | 120 ± 10 | 130 ± 11 | 110 ± 10 |
48 | 230 ± 18 | 210 ± 17 | 160 ± 15 | 130 ± 15 | 230 ± 18 | 214 ± 14 | 240 ± 12 | 210 ± 16 |
72 | 280 ± 20 | 260 ± 22 | 230 ± 20 | 180 ± 20 | 260 ± 22 | 290 ± 22 | 280 ± 21 | 270 ± 20 |
Compound | K-17 | A-3 | ||||||
dose (μg/ml) | Control | 1 | 10 | 100 | Control | 1 | 10 | 100 |
Hours after treatment 24 | 130 ± 12 | 120 ± 11 | 135 ± 11 | 110 ± 5 | 120 ± 11 | 120 ± 10 | 120 ± 10 | 12" ± 11 |
48 | 200 ± 15 | 220 ± 15 | 240 ± 10 | 210 ± 10 | 240 ± 14 | 110 ± 5 | 110 ± 10 | 110 ± 5 |
72 | 280 ± 17 | 280 ± 20 | 290 ± 19 | 290 ± 19 | 290 ± 20 | 110 ± 7 | 110 ± 5 | 100 ± 10 |