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Figure 1 | Cancer Cell International

Figure 1

From: 17β-Estradiol responsiveness of MCF-7 laboratory strains is dependent on an autocrine signal activating the IGF type I receptor

Figure 1

Effect of IGF-I and E2 on the induction of DNA-synthesis in the MCF-7 strains. Serum-starved cells grown in 24-wells plates were given no mitogens (-), 20 ng/ml of IGF-I (I(20)), 2 ng/ml of IGF-I (I(2)), 2 ng/ml of IGF-I in combination with 1 nM E2 (I(2)E2), or 1 nM E2 (E2) and were harvested after 30 h. 3H-thymidine (2 μCi/ml) was added to the culture 6 h before harvesting. Indicated values are means of triplicate measurements, and were normalized for the incorporation induced by 20 ng/ml of IGF-I (100%).

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