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Figure 3 | Cancer Cell International

Figure 3

From: Styrylpyrone Derivative (SPD) induces apoptosis in a caspase-7-dependent manner in the human breast cancer cell line MCF-7

Figure 3

Cleavage of procaspase-7 after SPD treatment. Proteins from MCF-7 cells treated with 10-6 M SPD for the indicated times were resolved on a 15% PAGE and submitted to Western Blotting using a monoclonal antibody against caspase-7 (B94-1), which recognizes the pro- (35-kDa) and the active (17-kDa) forms of caspase-7. Following SPD treatment, the caspase-7 proenzyme was cleaved, generating the catalytically-active 17-kDa fragment.

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