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Figure 4 | Cancer Cell International

Figure 4

From: Styrylpyrone Derivative (SPD) induces apoptosis in a caspase-7-dependent manner in the human breast cancer cell line MCF-7

Figure 4

Activation of caspase-7 after SPD-treatment. The activity of caspase-7 was measured with a Colorimetric Assay Kit (Chemicon) that recognizes cleavage of the sequence DEVD by active caspase-7. Caspase-7 activity increased when cells were treated with SPD, indicating the catalytic activation of this executioner caspase. When MCF-7 cells were incubated with the caspase-7 inhibitor, DEVD-CHO, prior to SPD treatment, caspase-7 DEVDase activity diminished.

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