Table 1 The percent of total fatty acid composition of linoleic acid (LA, n6 18-2), arachidonic acid (AA, n6 20-4), and docosahexaenoic acid (DHA, n3 22-6) in microsomal and in mitochondrial fractions of tumor, of liver and of colon following a two week dietary intervention of AIN·76 food formula without (-) and with (+) supplementation with synthetic vitamin E (2000 IU/kg dry food). Mean ± SD and number of mice (n) are listed.
Vitamin E supplement | Fraction | n | LA, 18-2a | AA, 20-4 | DHA, 22-6b |
|---|---|---|---|---|---|
Tumor | |||||
- | Micro | 4 | 8.7 ± 5.0 | 7.4 ± 12 | 0.3 ± 0.3 |
+ | " | 5 | 1.9 ± 2.1 | 7.9 ± 4.2 | 1.3 ± 1.3 |
- | Mito | 4 | 7.0 ± 5.9 | 9.6 ± 2.8 | 0.2 ± 0.5 |
+ | " | 5 | 4.4 ± 5.9 | 5.8 ± 3.7 | 2.3 ± 4.9 |
Liver | |||||
- | Micro | 4 | 12.9 ± 5.1 | 4.9 ± 1.8 | 1.0 ± 0.9 |
+ | " | 5 | 11.3 ± 1.7 | 5.4 ± 0.9 | 1.8 ± 0.3 |
- | Mito | 4 | 14.2 ± 1.5 | 8.0 ± 0.9 | 0.5 ± 0.1 |
+ | " | 5 | 12.9 ± 1.2 | 6.1 ± 1.8 | 1.4 ± 0.5 |
Colon | |||||
- | Micro | 3 | 5.3 ± 2.1 | 6.3 ± 2.2 | 0.3 ± 0.3 |
+ | " | 5 | 4.6 ± 1.2 | 4.1 ± 1.3 | 2.4 ± 1.1 |
- | Mito | 3 | 9.4 ± 2.1 | 2.9 ± 0.2 | 0.8 ± 0.5 |
+ | " | 5 | 6.3 ± 1.3 | 3.7 ± 1.6 | 1.8 ± 1.0 |