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Table 4 Results of quantitative RT-PCR for antioxidant enzyme gene expression in the heart of mice fed the AIN·76 food formula with (+) or without (-) a synthetic vitamin E supplement (2000 IU/kg dry food) for six weeks.

From: High dietary level of synthetic vitamin E on lipid peroxidation, membrane fatty acid composition and cytotoxicity in breast cancer xenograft and in mouse host tissue

  Enzymea
Vitamin E supplement GPX-1 CAT CZ SOD Mn SOD EC SOD HO-1b Mn SODb GPX-1
- .325 ± .019 .495 ± .048 .915 ± .038 2.106 ± .166 .064 ± .005 .020 ± .002 6.55 ± 0.56
+ .252 ± .028 .522 ± .029 .915 ± .054 2.538 ± .175 .059 ± .005 .013 ± .002 10.49 ± 1.16
  1. a Abbreviations: GPX-1 – glutathione peroxidase; CZ SOD – copper zinc superoxide dismutase; CAT – catalase; Mn SOD – manganese superoxide dismutase; EC SOD – extracellular superoxide dismutase; HO-1-inducible form of heme oxygenase b Means differ to significant extent using two-tailed t test. Data are presented as the mean ± SE number of transcripts for each mRNA after normalization to expression of beta actin. N = 5 mice per group.