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Table 4 Results of quantitative RT-PCR for antioxidant enzyme gene expression in the heart of mice fed the AIN·76 food formula with (+) or without (-) a synthetic vitamin E supplement (2000 IU/kg dry food) for six weeks.

From: High dietary level of synthetic vitamin E on lipid peroxidation, membrane fatty acid composition and cytotoxicity in breast cancer xenograft and in mouse host tissue

 

Enzymea

Vitamin E supplement

GPX-1

CAT

CZ SOD

Mn SOD

EC SOD

HO-1b

Mn SODb GPX-1

-

.325 ± .019

.495 ± .048

.915 ± .038

2.106 ± .166

.064 ± .005

.020 ± .002

6.55 ± 0.56

+

.252 ± .028

.522 ± .029

.915 ± .054

2.538 ± .175

.059 ± .005

.013 ± .002

10.49 ± 1.16

  1. a Abbreviations: GPX-1 – glutathione peroxidase; CZ SOD – copper zinc superoxide dismutase; CAT – catalase; Mn SOD – manganese superoxide dismutase; EC SOD – extracellular superoxide dismutase; HO-1-inducible form of heme oxygenase b Means differ to significant extent using two-tailed t test. Data are presented as the mean ± SE number of transcripts for each mRNA after normalization to expression of beta actin. N = 5 mice per group.
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Cancer Cell International

ISSN: 1475-2867

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