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Table 1 Different cancer cell lines are represented for their mean % survival in presence of different drugs as shown in Figure 2A.

From: Chemosensitivity assay in mice prostate tumor: Preliminary report of flow cytometry, DNA fragmentation, ion ratiometric methods of anti-neoplastic drug monitoring

Drug VP 16 (Dose)

Mean % survival with VP 16(n = 5)

Drug with PC3 cells

Endlabelling Fluorescence (A.U.)

 

LNCaP

PC3

DU145

Control Taxotere

2

2 μg/ml

85

96

75

10 nM

10

5 μg/ml

80

84

70

50 nM

10

10 μg/ml

85

82

65

Campothecin

 

20 μg/ml

80

72

55

200 nM

135

  1. Notice the most pronounced response of DU 145 followed by PC3 and LNCaP cell lines against VP 16 (20 μg/ml). Dynamic range of the mean endlabelling fluorescence intensity was normalized to arbitrary control value of 1.0 non-linear scale (n = 5). The combination of taxotere on PC3 was apparently saturated at 10 nM for 24 hours at about 10% of the campothecin dose, a near maximal response.