Molecular mechanisms of heptaplatin effective against cisplatin-resistant cancer cell lines: less involvement of metallothionein

Table 1 Comparison of cytotoxicities of the cisplatin analogs in various gastric cancer cell lines

^a, The 50% inhibitory concentration (IC₅₀) for a particular agent was defined as the drug concentration which results in a 50% reduction in cell number to the untreated control. IC₅₀ values were determined directly from semilogarithmic dose-response curves. The means were obtained from the experiments carried out at least in triplicate.
^b, The ratios of IC₅₀values of SNU-638 to that of SNU-601 (Fig. 4)
^c, The ratios of IC₅₀ values of SNU-601/Cis to that of SNU-601 (Fig. 5)
^d, The ratios of IC₅₀ values of SNU-601/MT to that of SNU-601/Mock (Fig. 7)
^e, The ratio calculated from extrapolated data obtained in SNU-601/MT (Fig. 7) *, P < 0.05 versus cisplatin or carboplatin group

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