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Table 1 Production of uPA by Breast Cancer Cells

From: Human breast cancer cell-mediated bone collagen degradation requires plasminogen activation and matrix metalloproteinase activity

Cells uPA (U/1 × 105 cells/24 h)
MDA-231 2.3
ZR-75-1 1.9
MCF-7 1.6
HME Undetected
  1. uPA was measured by a chromogenic assay (see Materials and methods) in serum-free conditioned medium collected over a 24 h period. Breast cells were cultured in the presence of plasminogen (2 ug/ml) and TGFβ (10-10 M). uPA was not detected in unstimulated breast cancer cells.