Table 2 Localization of κB binding motifs in the body suggests the functions of Rel/NF-κB [37].
From: Rel/Nuclear factor-kappa B apoptosis pathways in human cervical cancer cells
κB sites | Related functions |
|---|---|
IL-2, IL-2R, Igκ, MHC Classes I and II | Immune system reaction and responses. |
IL-1, IL-6, TNF-α, TNF-β, serum amyloid A protein | Inflammatory reactions and acute phase responses. |
HIV-LTR, SV 40, CMV, adenovirus | Viral infections |
Rel/NF-κB family (NF-κB1, NF-κB2, c-rel, RelB) | Immune system responses. |
p53, c-Myc, Ras, pRB1 | Growth regulation. |
IκB-α, IκB-γ, p105, p100 and Bcl-3 | IκB family members |
I-CAM, V-CAM, E-selectin, ELAM1 | Cell adhesion molecules |