Figure 6
From: In vitro analysis of the invasive phenotype of SUM 149, an inflammatory breast cancer cell line
6A. Model of passive metastasis. 6B. SUM 149 cell spheroids expressing RFP. 6A. Tumor cells secrete unknown differentiation factors, stimulating vasculogenesis and resulting in a cluster of tumor cells, termed embolus, located within the de novo formed vessel. The embolus maintains cell-cell attachments as it moves through the vessel and lodges within a dermal lymph node. 6B. 100× confocal projection image (10 images, Z = 20 μm) of SUM 149 cell spheroids stably expressing RFP in 3-dimensional matrigel culture after 5 days.