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Table 2 Omega-3 Fatty Acid Enriched Diet (n-3) and Gamma Irradiation Therapy (IR) on Blood Counts, (means ± SEM)

From: Dietary omega-3 fatty acids and ionizing irradiation on human breast cancer xenograft growth and angiogenesis

Therapy Group

n

WBC × 103/μL

RBC × 106/μL

Platelets × 103/μL

Micronuclei (%RBC)

Early Kill1

     

n-6

4

2.91 ± 0.83

9.08 ± 0.07

584 ± 76

1.3 ± 0.04

n-6/IR

4

0.11 ± 0.01

7.50 ± 0.16

389 ± 17

1.2 ± 0.03

n-3

7

2.02 ± 0.30

8.45 ± 0.12

634 ± 51

1.2 ± 0.03

n-3/IR

4

0.16 ± 0.03

7.66 ± 0.07

358 ± 78

1.5 ± 0.04

Late Kill2

     

n-6

8

1.85 ± 0.37

8.30 ± 0.14

551 ± 83

1.6 ± 0.06

n-6/IR

13

1.48 ± 0.32

7.06 ± 0.16

973 ± 98

1.1 ± 0.01

n-3

16

2.85 ± 0.42

8.31 ± 0.20

582 ± 61

1.3 ± 0.04

n-3/IR

10

0.92 ± 0.18

6.10 ± 0.40

918 ± 131

0.9 ± 0.03

  1. 1Mice euthanized one day after last irradiation treatment.
  2. 2Mice euthanized 22 days after last irradiation treatment.
  3. Results of Statistical Analyses:
  4. 1. At one day after the end of irradiation therapy, there were significant decreases in WBC, RBC, and platelet counts due to the irradiation. There were no other significant differences at p < 0.01.
  5. 2. At 22 days after the end of irradiation therapy, WBC and RBC counts were still significantly decreased and there was a significant increase in platelet counts due to irradiation. There were no other significant differences at p < 0.01.