Table 1 Intracellular targets of bortezomib.
From: Preclinical evaluation of the proteasome inhibitor bortezomib in cancer therapy
Protein | Function | Effect of bortezomib | References |
|---|---|---|---|
IκBα | Regulates the activity of the transcription factor, NF-κB | Stabilization | Hideshima et al [15], 2001 Russo et al [16], 2001 Sunwoo et al [17], 2001 Hideshima et al [18], 2002 Tan and Waldmann [19], 2002 Ma et al [20], 2003 |
JNK | Phosphorylates and activates the transcription factor c-Jun | Activation | Hideshima et al [21], 2003 Chauhan et al [22], 2004 Yang et al [23], 2004 |
p21, p27 | CDK inhibitors | Stabilization | Shah et al [24], 2001 Hideshima et al [15], 2001 Yang et al [23], 2004 |
p53 | Transcription factor and Tumor suppressor | Stabilization | Williams and McConkey [25], 2003 Hideshima et al [21], 2003 Yang et al [23], 2004 |
Bid | Proapoptotic protein | Stabilization | Breitschopf et al [26], 2000 |
Bax | Proapoptotic protein | Stabilization | Li and Dou [27], 2000 |
Caveolin-1 | Promotes cell migration | Inhibition of activation | Podar et al [28], 2004 |
gp130 | Cytokine signaling receptor | Downregulation | Hideshima et al [29], 2003 |
DNA-PKcs | DNA repair | Cleavage | Hideshima et al [21], 2003 |
ATM | DNA repair | Cleavage | Hideshima et al [21], 2003 |